The Essential Guide to the Differences Between Xeomin and Botox

Understanding the Choice Between Xeomin and Botox

When it comes to reducing wrinkles and enhancing facial rejuvenation, many people find themselves choosing between Xeomin and Botox. If you’re wondering about the difference between Xeomin and Botox, here’s a quick snapshot:

  • Xeomin: Known for its “naked” formula without accessory proteins.
  • Botox: Contains accessory proteins and has a longer track record.

Both are effective at treating dynamic wrinkles—those fine lines that appear from muscle movements like smiling or frowning. However, the choice between the two often comes down to your personal preferences and sensitivities.

Understanding which treatment to choose can be challenging, but knowing the key differences can make the decision easier. Xeomin and Botox both help smooth out wrinkles, but their formulations, onset of results, and even storage requirements differ. Each has unique characteristics that might make one a better fit for your skin and aesthetic goals.

As an Ivy League-trained, board-certified plastic surgeon with over two decades of experience, I, Dr. Thomas Jeneby, specialize in helping patients make informed choices about their cosmetic treatments. My practice has seen the transformative power of both Xeomin and Botox, and I’m here to guide you through the essentials.

Xeomin vs Botox Comparison Infographic - difference between xeomin and botox infographic comparison-2-items-casual

What Causes Lines and Wrinkles?

Nobody likes to admit it, but lines and wrinkles are a natural part of aging. Understanding what causes them can help you make informed choices about treatments like Xeomin and Botox.


Collagen is a fibrous protein that holds skin cells together, making the skin strong and smooth. As we age, collagen production decreases, leading to weaker skin and the formation of wrinkles. Environmental factors, like sun exposure, can speed up this process.


Elastin is another protein that helps skin maintain its flexibility. It allows your skin to snap back into place after being stretched. Over time, elastin breaks down, and skin loses its elasticity, leading to sagging and wrinkles.

Hyaluronic Acid

Hyaluronic acid is a sugar molecule that keeps your skin hydrated and plump. Young skin has plenty of it, giving it a dewy and supple appearance. As we age, our levels of hyaluronic acid decrease, leading to drier, less resilient skin.

Fat Repositioning

Facial fat pads give us our youthful contours. As we age, gravity pulls these fat pads downward, causing the skin to sag and wrinkles to form. This repositioning also makes areas like the cheeks and temples appear thinner, contributing to an aged look.

Contributing Factors

While aging is inevitable, some factors can speed up the process:

  • Genetics: Your genes play a significant role in how quickly you age.
  • Illnesses: Certain health conditions can accelerate aging.

Other factors you can control include:

  • Smoking: Accelerates skin aging.
  • Excessive alcohol consumption: Dehydrates the skin.
  • Poor diet: High sugar and processed foods break down collagen.
  • Lack of exercise: Reduces blood flow to the skin.
  • Stress: Increases cortisol, which can damage collagen and elastin.
  • Inadequate sleep: Affects skin’s ability to repair itself.
  • Dehydration: Makes skin more prone to wrinkles.
  • Excessive caffeine: Dehydrates the skin.
  • Poor skincare regimen: Fails to protect and nourish the skin.

The Importance of the Sun

The sun is a major culprit in premature aging. UV rays break down collagen and elastin, leading to wrinkles. Most people don’t protect themselves adequately from the sun, accelerating skin aging. Sunscreen is your best defense. Apply it daily—even when you’re indoors, as UV rays can penetrate windows.

Sun Exposure - difference between xeomin and botox

Key takeaway: Protecting your skin from the sun can significantly delay the onset of wrinkles.

Understanding these factors helps you take proactive steps in maintaining youthful skin. Next, let’s delve into the science behind Xeomin and Botox and how they can help you combat these signs of aging.

The Science Behind Xeomin and Botox

Botulinum Toxin Type A

Both Xeomin and Botox use Botulinum Toxin Type A. This is a neurotoxin derived from the bacterium Clostridium botulinum. It may sound scary, but in small, controlled doses, it can be very effective for reducing wrinkles and treating certain medical conditions.

Muscle Relaxants

When injected, these neurotoxins act as muscle relaxants. They block nerve signals that tell your muscles to contract. This “freezes” the muscle, reducing its activity. As a result, the skin above the muscle smooths out, diminishing the appearance of wrinkles.

Nerve Signals

The science behind this is fascinating. Normally, your nerves release a chemical called acetylcholine to make muscles contract. Botulinum Toxin Type A blocks the release of acetylcholine at the injection site. This prevents the muscle from contracting, effectively relaxing it and smoothing out the skin.

Injection Technique

The skill of the injector is crucial. Proper technique ensures that only the targeted muscles are affected. This helps achieve a natural look while preserving your ability to make facial expressions. A trained professional will know precisely where to inject to get the best results.

Understanding the science helps you see why these treatments are effective. Next, we’ll explore the key differences between Xeomin and Botox.

Key Differences Between Xeomin and Botox

When deciding between Xeomin and Botox, understanding their key differences can help you make an informed choice. Let’s break them down:


Botox and Xeomin are both derived from botulinum toxin type A. However, their formulations are different. Botox includes botulinum toxin A surrounded by accessory proteins. These proteins help protect the active molecule but can also cause allergic reactions in some people.

Xeomin, on the other hand, is a “naked” neurotoxin. It contains only the active ingredient, botulinum toxin A, without any accessory proteins. This pure form reduces the risk of antibody formation, making it a good option for those who may be sensitive to additives.

Accessory Proteins

The accessory proteins in Botox serve as a protective layer around the active toxin. While they can enhance stability, they also increase the likelihood of developing antibodies. Over time, these antibodies can make Botox less effective.

Xeomin skips these proteins altogether. This “naked” approach means a lower chance of antibody development, potentially offering longer-lasting effectiveness for some users.

Onset of Results

Both treatments provide temporary results, typically lasting 3-6 months. However, the onset of results can vary:

  • Botox: Results usually start appearing within 72 hours.
  • Xeomin: May take up to 4 days for full results to develop.

Storage Requirements

Storage might not seem like a big deal, but it can impact how and where treatments are offered:

  • Botox: Must be refrigerated before use to maintain its potency.
  • Xeomin: Does not require refrigeration, making it easier to store and transport.

These storage differences can make Xeomin more convenient for practitioners, potentially affecting availability and cost.

Quick Comparison Table

FormulationBotulinum toxin A + accessory proteinsPure botulinum toxin A (incobotulinumtoxinA)
Allergy RiskHigher due to accessory proteinsLower due to lack of accessory proteins
StorageRequires refrigerationNo refrigeration needed
Onset of Effects72 hoursUp to 4 days

Understanding these differences can help you decide which treatment aligns best with your needs and lifestyle. Next, we’ll dive into the efficacy and safety of both treatments.

Efficacy and Safety: Xeomin vs. Botox

When choosing between Xeomin and Botox, understanding their efficacy and safety is crucial. Both treatments have undergone extensive clinical studies, and here’s what we know:

Clinical Studies

Xeomin and Botox have been rigorously tested. Xeomin has shown effectiveness in treating dynamic wrinkles and medical conditions like cervical dystonia. Botox has a long track record in reducing facial wrinkles such as frown lines, crow’s feet, and neck bands. It’s also effective for excessive sweating.

Both treatments work by relaxing targeted muscles, reducing the appearance of lines and wrinkles. Clinical trials confirm significant reductions in wrinkles and fine lines with both products.

Side Effects and Adverse Effects

Common side effects for both Xeomin and Botox include:

  • Pain at the injection site
  • Bruising
  • Swelling

These side effects are usually mild and temporary. However, there are some differences in severe side effects:

  • Xeomin: Respiratory infections have been reported.
  • Botox: Rarely can lead to overactive bladders.

Expert Tip: Consult a qualified medical professional to assess potential risks based on your health history.

Recovery Time

Both Xeomin and Botox offer quick recovery times. Most people can return to their daily activities shortly after the procedure. Any redness or swelling typically subsides within a few hours to a couple of days.

Duration of Effectiveness

  • Xeomin: Effects last between three to six months.
  • Botox: Results last up to four to six months.

This slight variability depends on individual factors, but generally, both treatments are effective for a similar duration.

Key Takeaway: Both Xeomin and Botox are safe and effective, with mild and temporary side effects. The choice between them often comes down to personal preference and medical history.

Next, we’ll explore how to choose the right treatment for you, considering your goals, medical history, and other important factors.

Choosing the Right Treatment for You

When deciding between Xeomin and Botox, several factors can guide your choice. Let’s break down the key considerations to help you make an informed decision.

Personal Goals

Your unique objectives are crucial. Are you targeting specific wrinkles, like frown lines or crow’s feet? Or perhaps you need treatment for a medical condition such as excessive sweating? Understanding your goals helps tailor the treatment to your needs.

For example, if you’re looking for a “naked” injectable without accessory proteins, Xeomin might be your preference. On the other hand, if you prefer a well-established track record, Botox is widely recognized.

Medical History

Your medical history plays a significant role. Consulting with a qualified medical professional is essential to assess potential risks. For instance, if you have a sensitivity to accessory proteins, Xeomin might be a better option since it lacks these additives.

Dr. Ranasinghe emphasizes, “Both products are safe and effective options for improving the appearance of fine lines and wrinkles on the face. The best choice for you will depend on your needs and concerns, along with consulting your physician.”

Cost Considerations

The cost of Xeomin and Botox can vary based on several factors:

  • Geographic location
  • Size and scope of the treatment area
  • Type of institution (MedSpa vs. board-certified dermatologist)

Generally, the cost is calculated based on the number of units required. While Xeomin is often noted for being slightly cheaper, it’s important to discuss pricing with your provider to ensure it aligns with your budget.

Flexible Treatment Intervals

Both treatments offer flexibility in scheduling follow-up appointments. After your initial session, results typically last several months. You can plan subsequent treatments based on your preferences and lifestyle.

Xeomin: Effects last between three to six months.

Botox: Results last up to four to six months.

This flexibility allows you to maintain your desired look without disrupting your daily routine.

Why Choose Spa Black?

At Spa Black, we specialize in personalized treatment plans, ensuring your needs and concerns are comprehensively addressed. Our team of skilled professionals is trained in the precise injection techniques necessary to achieve natural-looking results.

By choosing Spa Black, you gain access to:

  • Expert administration by board-certified professionals
  • Tailored solutions using both Xeomin and Botox
  • A commitment to excellence and patient satisfaction

Your journey to a more youthful and radiant appearance is in expert hands at Spa Black. Schedule a consultation with us today to take the first step towards achieving your cosmetic goals.

Next, we’ll dive into the conclusion, summarizing the key points and why Spa Black is your best choice for injectable treatments.


Choosing between Xeomin and Botox can feel overwhelming, but it doesn’t have to be. At Spa Black, we make the decision easy by offering expert guidance and personalized treatment plans.

Why Choose Spa Black?

  1. Expert Administration: Our board-certified professionals ensure that your treatments are safe and effective. With their extensive knowledge of facial anatomy and injection techniques, you can trust that you’re in good hands.

  2. Tailored Solutions: Whether you’re interested in Xeomin or Botox, we customize your treatment to meet your unique needs and goals. We consider your medical history, personal preferences, and desired outcomes to develop a plan just for you.

  3. Commitment to Excellence: Patient satisfaction is our top priority. We strive for natural-looking results that enhance your beauty and boost your confidence.

  4. Convenient Options: With flexible treatment intervals and competitive pricing, we make it easy to maintain your youthful appearance without breaking the bank.

At Spa Black, we believe that everyone deserves to look and feel their best. Our team of skilled professionals is dedicated to helping you achieve a more youthful and radiant appearance through safe and effective injectable treatments.

Ready to take the next step? Schedule a consultation with us today and discover how Xeomin or Botox can help you achieve your cosmetic goals.

Your journey to a more youthful appearance starts here. Visit Spa Black, where your beauty and satisfaction are our top priorities.