Evaluating the Effectiveness: Botox or Xeomin?

Understanding Botox and Xeomin for a Youthful Appearance

When exploring anti-wrinkle treatments today, a common question arises: is botox better than xeomin? The short answer is that it depends on individual needs and preferences. Here’s a quick comparison:

  • Duration of Results: Both last around 3-4 months.
  • Cost: Similar pricing, though it can vary by provider.
  • Allergic Reactions: Xeomin may have fewer due to its purer formulation.
  • Speed of Results: Both typically show results within a week.
  • Formulation: Botox has complexing proteins while Xeomin does not.

Both Botox and Xeomin are key players in the realm of botulinum toxin type A treatments, targeting aging concerns like dynamic wrinkles caused by repetitive facial movements. These non-invasive injectables work by temporarily paralyzing the muscles to smooth out lines and restore a youthful appearance.

In the pursuit of ageless beauty, selecting between these treatments requires understanding their unique traits. Botox, famed for over a decade, contains accessory proteins, whereas Xeomin boasts a “naked” form, potentially reducing the risk of allergic reactions.

By better understanding these distinctions, you can make an informed decision that best suits your goals and lifestyle.

Comparison infographic of Botox and Xeomin - is botox better than xeomin infographic comparison-2-items-formal

I’m Dr. Thomas Jeneby, an Ivy League trained, board-certified plastic surgeon. With over two decades of experience in botulinum toxin treatments, I’m here to help you navigate whether botox is better than xeomin for you.

Ready to dive deeper? Let’s explore more on how each of these treatments can enhance your natural beauty.

Is Botox Better Than Xeomin?

When deciding between Botox and Xeomin, several factors come into play. Let’s break down the key differences to help you make an informed choice.

Duration of Results

Botox typically lasts for 3-4 months. Patients often schedule treatments quarterly to maintain their smooth, youthful appearance.

Xeomin, on the other hand, can last a bit longer. Some studies suggest effects lasting up to 5 months. This can be particularly beneficial for those looking to space out their treatments more.

Cost Considerations

The cost of Botox and Xeomin depends on several factors, including geographic location, the size and scope of the treatment area, and the type of institution at which you are receiving your treatment. The cost is partially calculated based off of how many units of the injection you require for treatment or areas which need treatment. Furthermore, the cost of treatment can increase if you are receiving the treatment from a board-certified dermatologist as opposed to a MedSpa or nurse. However, the risk of developing more serious side effects is greatly reduced if you receive treatment from an expert dermatologist, such as Dr. Green.

Allergic Reactions

One notable difference between Botox and Xeomin is their formulation.

Botox contains accessory proteins that act as preservatives. These proteins can sometimes trigger allergic reactions in sensitive individuals.

Xeomin is often referred to as the “naked” injectable because it contains only the active ingredient, incobotulinumtoxinA, without any accessory proteins. This simpler formulation can reduce the risk of allergic reactions and may be better for those with sensitivities.

Speed of Results

One of the significant differences between Xeomin and Botox is the onset of results.

Botox: Results usually start to appear within 7-14 days after the injection.

Xeomin: Results can show up more quickly, often within 3-5 days. This faster onset is due to Xeomin’s purer formulation, which lacks the accessory proteins found in Botox.

Formulation Differences

The main difference between Botox and Xeomin is how they are made.

Botox is a mixture of proteins, including additives that may trigger allergies.

Xeomin is formulated with only botulinum Type A, which lowers the risk of allergies. Since Xeomin lacks additives, it may not need to be refrigerated, which can extend its shelf life. However, a lack of additives may also mean that Xeomin may not be as effective as Botox.

Summary Table

Duration3-4 months3-5 months
Allergic ReactionsPossible due to accessory proteinsLower risk due to simpler formulation
Speed of Results7-14 days3-5 days
FormulationContains accessory proteinsPure botulinum toxin Type A

Understanding these differences can help you make an informed decision about which treatment might be best for you. Next, let’s explore the key differences between Botox and Xeomin in more detail.

Key Differences Between Botox and Xeomin


One of the most significant differences between Botox and Xeomin is their formulation. Botox contains accessory proteins along with the active ingredient, botulinum toxin type A. These proteins act as preservatives but can sometimes lead to the body developing antibodies, which might reduce the treatment’s effectiveness over time.

On the other hand, Xeomin is known as the “naked injectable.” It contains only purified botulinum toxin type A without any accessory proteins. This simpler formulation means there is less chance for the body to develop antibodies, potentially making Xeomin a more consistent option for long-term use.

Accessory Proteins

The absence of accessory proteins in Xeomin is a key factor that sets it apart from Botox. These proteins in Botox can sometimes trigger allergic reactions or lead to resistance, reducing the treatment’s effectiveness. According to Dr. Ranasinghe, “With this purified form, the belief is that the risk for allergic reactions is also less with Xeomin compared to traditional Botox.”

FDA Approval

Both Botox and Xeomin have been approved by the FDA for various treatments. Botox has a broader range of FDA-approved uses, including:

  • Chronic migraines
  • Overactive bladder
  • Hyperhidrosis (excessive sweating)
  • Cervical dystonia
  • Upper limb spasticity

Xeomin is also FDA-approved but primarily for treating dynamic wrinkles and cervical dystonia. While both are effective, Botox’s wider range of approved medical uses might make it more versatile for some patients.

Treatment Areas

For cosmetic purposes, both Botox and Xeomin are effective in treating:

  • Frown lines (wrinkles between the eyebrows)
  • Forehead lines (horizontal lines on the forehead)
  • Crow’s feet (wrinkles around the eyes)

However, the choice between the two often comes down to personal preference and specific treatment goals. Some patients may find that Xeomin’s “naked” formulation works better for them, especially if they have developed resistance to Botox.

“Naked Injectable”

Xeomin’s “naked” injectable nature is one of its most appealing features. The lack of additional proteins can reduce the risk of allergic reactions and make the treatment more effective for a longer period. This simplicity can be particularly beneficial for patients who have experienced reduced effectiveness with Botox due to antibody formation.

Understanding these key differences can help you decide whether Botox or Xeomin is the right choice for you. Next, we’ll delve into the benefits of choosing Xeomin over Botox.

Benefits of Choosing Xeomin Over Botox

When it comes to choosing between Botox and Xeomin, it’s important to understand the unique advantages of Xeomin. Here are some key benefits that might make Xeomin the better option for you:

Longer-Lasting Results

One of the standout benefits of Xeomin is its potential for longer-lasting results. While Botox generally lasts about 3-4 months, some studies suggest that Xeomin can last up to 5 months for certain individuals. This means fewer trips to the dermatologist and longer periods of enjoying wrinkle-free skin.

Fewer Allergic Reactions

Xeomin is often referred to as a “naked” injectable because it contains only the active ingredient, Botulinum Toxin Type A, without any accessory proteins. This simpler formulation can reduce the risk of allergic reactions. Dr. Ranasinghe notes, “With this purified form, the belief is that the risk for allergic reactions is also less with Xeomin compared to traditional Botox.”

Faster Visible Results

If you’re looking for quicker results, Xeomin might be the way to go. According to research, Xeomin’s effects can start to appear within 3-5 days, whereas Botox typically takes 7-14 days to show results. This faster onset is due to Xeomin’s purer formulation, which allows the active ingredients to work more quickly.

Purity of Formulation

The purity of Xeomin’s formulation is another major advantage. Since it lacks the accessory proteins found in Botox, the body doesn’t need to break down these extra proteins before the active ingredient starts working. This not only speeds up the onset of results but also reduces the likelihood of developing resistance to the treatment over time.

Xeomin Injection - is botox better than xeomin

Summary Table

Duration3-4 months3-5 months
Onset of Results7-14 days3-5 days
Allergic ReactionsHigher riskLower risk
FormulationContains proteinsPure Botulinum Toxin Type A

These benefits make Xeomin an attractive option for many patients. However, the choice between Botox and Xeomin should always be personalized based on your specific needs and circumstances.

Next, we’ll discuss the side effects and considerations you should keep in mind when choosing your treatment.

Side Effects and Considerations

When considering Botox or Xeomin treatments, understand the potential side effects and other considerations for each option. Let’s break it down:

Common Side Effects

Both Botox and Xeomin share similar common side effects. These usually occur at the injection site and are typically mild and temporary:

  • Pain
  • Bruising
  • Swelling
  • Redness

These symptoms often subside within a few hours to a few days. Avoiding anti-inflammatory medications before your appointment can help reduce these risks.

Rare Adverse Effects

While rare, there are more severe side effects to be aware of:

  • Drooping eyelids (ptosis)
  • Muscle weakness
  • Headaches
  • Flu-like symptoms

In extremely rare cases, if the neurotoxin spreads beyond the injection site, more serious issues can arise, such as:

  • Difficulty breathing
  • Vision problems
  • Trouble swallowing

These severe side effects are uncommon but highlight the importance of choosing a skilled, board-certified professional for your treatment.

Allergic Reaction Potential

One of the key differences between Botox and Xeomin lies in their formulations. Botox contains accessory proteins that can potentially trigger an allergic reaction in some patients. Xeomin, being a “naked injectable,” lacks these additional proteins, which may reduce the risk of allergic reactions.

Dr. Ranasinghe notes, “With this purified form, the belief is that the risk for allergic reactions is also less with Xeomin compared to traditional Botox.”

Post-Treatment Care

Proper post-treatment care can help minimize side effects and ensure the best results. Here are some tips:

  • Avoid strenuous activities for 24 hours.
  • Do not rub or massage the treated area.
  • Stay upright for at least 4 hours post-injection.
  • Avoid alcohol and blood-thinning medications for a day or two.

By following these guidelines, you can help reduce the chances of bruising and swelling and ensure a smoother recovery.

Next, we’ll guide you through choosing the right treatment for you, considering your personal goals, medical history, and lifestyle factors.

Choosing the Right Treatment for You

When deciding between Botox and Xeomin, several factors come into play. Let’s break them down:

Personal Goals

What are you hoping to achieve?

Some people want to smooth out fine lines and wrinkles, while others might be looking to address specific medical conditions like migraines or excessive sweating. Your goals will help determine which treatment is best.

  • Cosmetic goals: If you’re looking to reduce wrinkles, both Botox and Xeomin are effective. However, some people prefer Xeomin because it is a “naked injectable” and may offer a more natural look.
  • Medical goals: Botox has been FDA-approved for a wider range of medical conditions, so it might be the better choice if you’re looking for medical treatment.

Medical History

Your medical history matters.

Your past health issues and current medications can impact which treatment is safer for you. For example:

  • Allergic reactions: Xeomin might be a better option if you have a history of allergic reactions to Botox, as it contains fewer proteins.
  • Previous treatments: If you’ve used Botox before and it has been effective, you might want to stick with it. However, if you’ve developed resistance, Xeomin could be a better alternative.

Lifestyle Factors

Consider your daily routine and lifestyle.

Your lifestyle can also influence which treatment is more suitable:

  • Activity level: If you have a very active lifestyle, you might prefer Xeomin for its quicker onset of results.
  • Budget: Botox tends to be more expensive than Xeomin. If cost is a significant factor, Xeomin might be the more budget-friendly option.

Consultation Importance

Consulting a professional is crucial.

Before making a decision, a consultation with a qualified medical professional is essential. They can assess your facial anatomy, discuss your goals, and recommend the best treatment for you.

“The best choice for you will depend on your needs and concerns, along with consulting your physician,” says Dr. Ranasinghe.

Spa Black

Why choose Spa Black?

At Spa Black, we prioritize your uniqueness. Our skilled professionals specialize in personalized treatment plans. Whether you’re seeking cosmetic enhancements or relief from medical conditions, we provide tailored solutions using both Xeomin and Botox.

Our board-certified professionals are trained to deliver precise and safe treatments, ensuring you achieve natural-looking results with minimal risk of side effects.

By choosing Spa Black, you gain access to a range of treatments and personalized plans, all delivered with a commitment to excellence and patient satisfaction.

Next, we will wrap up our discussion by highlighting the importance of personalized care and professional consultation in making an informed decision.


Choosing between Botox and Xeomin can feel overwhelming, but it doesn’t have to be. At Spa Black, we believe in the power of personalized care to make your journey smooth and effective.

Personalized Care at Spa Black

We understand that every face is unique. Our team tailors treatments to meet your specific needs and goals. Whether you’re looking for a youthful appearance or need treatment for a medical condition, we’ve got you covered.

Importance of Professional Consultation

Consulting with a qualified professional is crucial. Our board-certified experts have deep knowledge of facial anatomy and injection techniques. This ensures you get natural-looking results with minimal risk of side effects.

Making an Informed Decision

Your decision should be based on your goals, medical history, and lifestyle. We recommend discussing these factors during your consultation to create a treatment plan that suits you best.

Ready to take the next step?

Schedule a consultation with us today and let us help you achieve a refreshed, youthful appearance. Your journey to looking and feeling your best starts here.