Decoding the Differences: Xeomin and Botox Explained

Understanding Xeomin vs Botox: A Quick Overview

When it comes to exploring what is xeomin vs botox, it all boils down to understanding their subtle differences in formulation, application, and results. Both treatments are popular for anti-aging and reducing wrinkles, but knowing which one is right for you can be crucial.

Quick Comparison:

  • Xeomin:
  • Contains only the active ingredient, incobotulinumtoxinA
  • Less likely to cause allergic reactions
  • Does not require refrigeration

  • Botox:

  • Contains additional proteins
  • Well-known brand with a long track record
  • Often preferred for broader medical uses

Facial wrinkles and lines are often the first signs of aging that people want to address. Anti-wrinkle treatments like Xeomin and Botox, both derived from botulinum toxin type A, offer a solution by temporarily relaxing facial muscles to smooth these lines.

Hi, I’m Dr. Thomas Jeneby. With over 20 years of experience as an Ivy League-trained, board-certified plastic surgeon, I’ve performed thousands of procedures, including Botox and Xeomin. Let’s dive into these injectables to uncover which might be the best fit for you.

Xeomin vs Botox Infographic - what is xeomin vs botox infographic comparison-2-items-formal

What is Xeomin?

Xeomin, known scientifically as incobotulinumtoxinA, is derived from botulinum toxin type A. It’s a neuromodulator that temporarily relaxes muscles, helping to reduce wrinkles and fine lines. What sets Xeomin apart is its “naked” injectable nature, meaning it contains only the active molecule without any accessory proteins. This simplicity can be a significant advantage for those who may develop antibodies against the additional proteins found in other treatments like Botox.

FDA Approval

Xeomin received FDA approval in 2010 for both cosmetic and medical uses. Cosmetically, it’s approved to treat moderate to severe frown lines between the eyebrows, also known as glabellar lines. On the medical side, Xeomin is approved to treat conditions like cervical dystonia (a painful neck muscle spasm) and blepharospasm (uncontrollable blinking).

Non-Cosmetic Uses

Beyond its cosmetic applications, Xeomin has several non-cosmetic uses. It’s used to treat:

  • Cervical dystonia: This condition causes painful muscle contractions in the neck.
  • Blepharospasm: Involuntary twitching of the eyelids.
  • Upper limb spasticity: Muscle stiffness in the arms.
  • Chronic sialorrhea (drooling): Approved for both adults and children.

These approvals highlight Xeomin’s versatility and effectiveness across various medical conditions, making it a valuable tool in both cosmetic and therapeutic settings.

Xeomin Injection - what is xeomin vs botox

Next, we will explore the intricacies of Botox, another popular botulinum toxin treatment, and how it compares to Xeomin.

What is Botox?

Botox, known scientifically as onabotulinumtoxinA, is another widely used botulinum toxin treatment. Like Xeomin, Botox has received FDA approval for both cosmetic and medical uses, making it a versatile option for many patients.

Accessory Proteins

One key difference between Botox and Xeomin is the presence of accessory proteins in Botox. These proteins act as preservatives but can sometimes lead to the body developing antibodies. Over time, this may reduce the treatment’s effectiveness in some individuals. Despite this, Botox remains a popular choice due to its long track record and well-documented results.

Wide Range of Uses

Botox is not just for smoothing out wrinkles. It’s approved to treat a variety of medical conditions, including:

  • Chronic migraines: Botox can help reduce the frequency of migraine headaches.
  • Overactive bladder: It provides relief for those suffering from frequent urination.
  • Hyperhidrosis: This condition causes excessive sweating, particularly in the underarms, hands, and feet.
  • Cervical dystonia: Similar to Xeomin, Botox is used to treat painful neck muscle contractions.
  • Upper limb spasticity: Botox helps alleviate muscle stiffness in the arms.

Cosmetic Uses

For cosmetic purposes, Botox is FDA-approved to treat:

  • Frown lines: Wrinkles between the eyebrows.
  • Forehead lines: Horizontal lines that appear on the forehead.
  • Crow’s feet: Wrinkles around the eyes.

Botox works by temporarily blocking nerve signals to the muscles, causing them to relax. This reduces the appearance of wrinkles and prevents new ones from forming.

Next, we will delve into a detailed comparison of Xeomin and Botox, examining their efficacy, formulation differences, side effects, cost, and ideal candidates.

Comparing Xeomin and Botox

Efficacy and Duration

Both Xeomin and Botox are effective for reducing wrinkles and treating various medical conditions. However, there are some differences in how quickly they work and how long their effects last.

  • Onset of Action: Xeomin typically shows results within 5 days, while Botox may take 7-14 days.
  • Duration of Results: Both products generally last between 3 to 6 months. Individual experiences can vary, but Xeomin has been noted to sometimes last a bit longer.

Formulation Differences

The primary distinction between Xeomin and Botox lies in their formulation:

  • Botox: Contains botulinum toxin type A along with accessory proteins. These proteins act as preservatives but may also trigger allergies in some people.
  • Xeomin: Known as the “naked” injectable, it contains only purified botulinum toxin type A without any accessory proteins. This can be beneficial for those who may develop antibodies against the additional proteins in Botox.

Side Effects and Safety

Both treatments are generally safe but come with potential side effects:

  • Common Side Effects: Redness, swelling, and bruising at the injection site are common for both Xeomin and Botox. These usually subside within a few hours to days.
  • Rare Adverse Effects: More severe side effects are rare but can include muscle weakness, difficulty breathing, and vision problems. Consultation with a qualified medical professional is crucial to minimize risks.

Cost and Accessibility

  • Treatment Costs: The cost of treatments can vary based on the provider, treatment area, and product quantity. Generally, Xeomin tends to be slightly more affordable than Botox.
  • Insurance Coverage: Cosmetic treatments are typically not covered by insurance. However, medical uses of botulinum toxin injections may be covered, depending on the condition being treated and the insurance policy.

Ideal Candidates

Choosing between Xeomin and Botox depends on various factors:

  • General Health: Both treatments are suitable for healthy adults. A thorough medical history review is essential to rule out any contraindications.
  • Age Restrictions: Generally, these treatments are recommended for adults over the age of 18. There are no upper age limits as long as the individual is in good health.
  • Allergy Considerations: Xeomin’s lack of accessory proteins makes it a better choice for those with allergies or sensitivities to the additional proteins found in Botox.

Next, we will address some frequently asked questions about Xeomin and Botox to help you make an informed decision.

Frequently Asked Questions about Xeomin and Botox

Is Xeomin better than Botox?

It depends on your needs. Both Xeomin and Botox are effective for reducing wrinkles and treating certain medical conditions. However, they have slight differences:

  • Xeomin: Known as the “naked injectable,” Xeomin is a purer form of botulinum toxin type A without accessory proteins. Some studies suggest it might work faster and last longer for certain individuals. It’s also less likely to cause allergic reactions.

  • Botox: Contains accessory proteins that act as preservatives. It has a longer track record and is FDA-approved for a wider range of medical conditions, including chronic migraines and excessive sweating.

Consult a healthcare provider to determine which is best for you based on your specific goals and medical history.

Who should not use Xeomin?

While Xeomin is generally safe, certain individuals should avoid it:

  • Pregnant or breastfeeding women: The effects on unborn or nursing babies are unknown.
  • People with certain neurological conditions: Conditions like ALS or myasthenia gravis could be exacerbated.
  • Allergy to botulinum toxin: If you’ve had allergic reactions to botulinum toxin products in the past, Xeomin might not be safe for you.
  • Infection at the injection site: Wait until any infections or skin conditions are fully healed.

Always consult a healthcare provider to ensure Xeomin is safe for you.

Is 20 units of Xeomin the same as 20 units of Botox?

Not exactly. While both are measured in units, the effectiveness can vary:

  • Dosage: 20 units of Xeomin might not produce the same effects as 20 units of Botox for every individual. Some people report needing more units of Xeomin to achieve similar results.
  • Cost: Xeomin tends to be slightly cheaper per unit, but you’ll need to consider the total number of units required.

Discuss with your provider to determine the appropriate dosage for your specific needs.

In the next section, we’ll dive into the benefits of choosing Spa Black for your Xeomin or Botox treatments.


Choosing the right treatment between Xeomin and Botox boils down to your unique needs and preferences. Both options offer effective solutions for reducing wrinkles and improving facial aesthetics, but there are some differences to consider.

Xeomin is known for its “naked” formula, containing only the active botulinum toxin type A without additional proteins. This can be beneficial for those who may develop antibodies to the accessory proteins found in Botox. On the other hand, Botox has a long track record and is well-known for treating various cosmetic and medical conditions.

Why Choose Spa Black?

At Spa Black, we specialize in personalized treatment plans tailored to your specific needs. Our team of board-certified professionals ensures precise injection techniques, guided by a deep understanding of facial anatomy. This expertise is crucial for achieving natural-looking results while minimizing the risk of side effects.

We prioritize your uniqueness and strive to provide the best care possible. Whether you are seeking cosmetic enhancements or relief from medical conditions, we offer a range of treatment options, including both Xeomin and Botox.

Join the ranks of our satisfied clients who value our commitment to excellence and patient satisfaction. Your journey towards a refreshed, youthful appearance starts with a consultation at Spa Black.

Visit our injectables page to learn more about how we can help you achieve your aesthetic goals. Schedule a consultation today and take the first step towards a rejuvenated you.

With the right information and expert guidance, you can confidently choose the treatment that best suits your needs. At Spa Black, your journey to a more youthful and radiant appearance is in expert hands.